EFEITO DO EXERCÍCIO FÍSICO NO VOLUME TUMORAL DE CAMUNDONGOS C57BL/6 COM MELANOMA CUTÂNEO

Abstract

Abstract: Objective: The present study investigated the effects of resistance exercise on tumor volume in C57BL/6 mice with cutaneous melanoma. Material and Methods: Sixteen (16) female C57BL/6 mice were used for the experiment, aged 10-12 weeks, with approximately 20 ± 5 g of body weight. The groups were divided into 2 groups: I. control group (n=8) and II. experimental group (n=8). Tumor volume assessments occurred 7 and 13 days after inoculation. The experimental group started resistance exercise 7 days before inoculation, on the day of inoculation there was no resistance exercise session. The control group was kept in the housing of autoclavable polypropylene boxes described above. The confidence level adopted in all analyzes will be fixed at 95% (p < 0.05). The Shapiro-Wilk test was performed to verify normality. After such analysis, the Mann-Whitney test was performed. Results: The growth of tumor volume in the control group compared to the experimental group had no significant difference (p=1,000). It is important to point out that the delta value presented in the control group (Δ = 521.71 +174.29) was higher than the mean of the experimental group (Δ = 413.45 +440.29). Conclusion: Resistance exercise did not promote tumor growth delay.