EFEITO DO EXERCÍCIO RESISTIDO NA FORÇA MUSCULAR DE CAMUNDONGOS C57BL/6 COM CAQUEXIA ASSOCIADA AO MELANOMA CUTÂNEO EXPERIMENTAL SINGÊNICO

Abstract

ABSTRACT: Objective: The purpose of this study is to evaluate the effect of different formats of resistance training on muscle strength in C57BL/6 mice cachexia associated with cutaneous melanoma. Material and methods: The mice were divided into 2 groups: I. training group (n=8) and II. training group 2 (n=8). The first evaluation of muscle strength took place 7 days before inoculation, and the second 15 days after inoculation. Training 2 took place after all animals had cachexia, all animals were diagnosed with cachexia on the tenth day after inoculation. Results: The results shown in table 01 are from the first and second evaluation of absolute strength and relative strength, of the front limbs of mice C57BL/6 with cachexia associated to the cutaneous melanoma that will accomplish, two different resistance training planning. In training 1 the absolute and relative force delta values were respectively - 4,03 + 1,31 g e - 0,22 + 0,16 g/g. Already in training 2 the absolute and relative force delta values were respectively - 3,17+ 1,28 e - 0,54+ 0,36 g/g. When performing the inferential analysis of delta values between the trainings, there is no significant difference in the decrease. Conclusion: The training proposals did not cause improvement in muscle strength in mice C57BL/6 with cachexia associated to the cutaneous melanoma. The results of this study, evidence the need for further research investigating the question of resistance exercise proposals in improving both absolute and relative strength in cancer issues related to cachexia.