Therapeutic alternatives with mouthwashes for management oral mucositis: an integrative review

Autores

DOI:

10.46551/ruc.v27n1a5

Resumo

Objective: The aim of this study was to conduct an integrative review to assess the efficacy of the mouthwashes recommended for the prevention and treatment of Oral mucositis (OM) and oropharyngeal mucositis (OPM) in patients undergoing cancer treatment. Method: The research question was formulated based on the PICOS strategy: “Are chlorhexidine, allopurinol, benzydamine and propolis mouthwashes effective in preventing and treating OM and OPM in patients undergoing cancer treatment?” Searches were performed in PubMed, Embase, Scopus, Web of Science, OpenGrey and Google Scholar, without publication year or language restrictions. Randomized clinical trials comparing the use of chlorhexidine, allopurinol, benzydamine and propolis with a control group or a group that did not undergo any intervention were included. The retrieved articles were analyzed and selected by two reviewers and disagreements were resolved by consultation with a third reviewer. Results: After evaluation of the works, 13 of 1183 articles were selected. Mouthwashes containing propolis and benzydamine mouthwashes were promising and effective in the management of mucositis while chlorhexidine or allopurinol did not provide satisfactory results. Conclusion: Mouthwashes could be an alternative for treatment or preventing oral mucositis in cancer patients. Services could consider the possibility of incorporating these medications since, in most cases, they are low cost and do not require specialized staff in their use.

Downloads

Não há dados estatísticos.

Biografia do Autor

Fernanda Pereira Delgado Costa, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil.

Mestrado Profissional em Odontologia em Saúde Pública, Colegiado de Pós-graduação em Odontologia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil.

Maria Luisa Leandro de Souza Dias, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil.

Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil.

Pedro Henrique Gonçalves Ferreira, Universidade Federal de Minas Gerais - UFMG

Mestrando em Odontologia em Saúde Pública pela Universidade Federal de Minas Gerais - UFMG (Mestrado Profissional, 2023-2025). Cirurgião-Dentista graduado pela Pontifícia Universidade Católica de Minas Gerais - PUC Minas (2020). Possui Residência em Saúde da Família pelo Hospital Universitário Clemente de Faria, Universidade Estadual de Montes Claros - Unimontes (Biênio 2021-2023). Realizou estágio optativo em Odontologia Hospitalar pelo Programa de Residência Multiprofissional em Saúde - Área de concentração: Cuidado Humanizado da Criança e Adolescente, do Hospital das Clínicas da UFMG/EBSERH (Outubro/2022). Membro da Câmara Técnica de Saúde Coletiva do Conselho Regional de Odontologia de Minas Gerais - CRO MG. Experiência na área da Saúde, ênfase em Odontologia Social e Preventiva, com interesse e atuação principalmente nos temas: Saúde Pública e Coletiva, Saúde da Família e Qualidade de Vida.

Karla Emília de Sá Rodrigues, Hospital de Amor, Barretos, São Paulo, Brasil.

Hospital de Amor, Barretos, São Paulo, Brasil.

Lucas Guimarães Abreu, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil.

Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil.

Tarcília Aparecida Silva, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil.

Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil.

Denise Vieira Travassos, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil.

Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil.

Referências

ELAD, S. et al. Immediate pain alleviation in oral mucositis and other oral ulcerative diseases through photobiomodulation therapy: the preemptive treatment concept. Quintessence International, v. 55, n. 6, 2024.

SONIS, S. T. Mucositis: The impact, biology and therapeutic opportunities of oral mucositis. Oral Oncology, v. 45, n. 12, p. 1015–1020, dez. 2009.

HONG, C. H. L. et al. Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines. Supportive care in cancer, v. 27, p. 3949-3967, 2019.

COURTOIS, E. et al. Mechanisms of PhotoBioModulation (PBM) focused on oral mucositis prevention and treatment: a scoping review. BMC Oral Health, v. 21, n. 1, p. 220, 2021.

GEORGAKOPOULOU, E. A.; KOSTAKIS, Georgios. Topical agents for the prevention and treatment of oral mucositis. Wiadomosci Lekarskie (Warsaw, Poland: 1960), v. 75, n. 9 pt 1, p. 2121-2125, 2022.

HERMONT, A. P. et al. Revisões integrativas em Odontologia : conceitos, planejamento e execução. Arquivos em Odontologia, v. 57, p. 3–7, 2021.

SOUZA, M. T.; SILVA, M. D.; CARVALHO, R.. Integrative Review: What Is It? How to Do It? Einstein (São Paulo), v. 8, n. 1, p. 102–106, mar. 2010.

DAL, K. et al. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto Contexto Enferm, Florianópolis, 2008 Out-Dez; 17(4): 758-64

PAGE, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, v. 372, 2021.

LOPRINZI, C. L. et al. A controlled evaluation of an allopurinol mouthwash as prophylaxis against 5‐fluorouracil‐induced stomatitis. Cancer, v. 65, n. 8, p. 1879-1882, 1990.

NAZARI, M. A. et al. Allopurinol mouthwash may prevent mucositis in patients undergoing 5-fluorouracil chemotherapy. Journal of Clinical Oncology, v.25, n. 24, p. 3886–3890, 2007

KUMAR, P. D. M. et al. The effect of three mouthwashes on radiation-induced oral mucositis in patients with head and neck malignancies: a randomized control trial. Journal of Cancer Research and Therapeutics, v. 4, n. 1, p. 3-8, 2008.

SHABANLOEI, R. et al. Alloporinol, chamomile and normal saline mouthwashes for the prevention of chemotherapy-induced stomatitis. Journal of Clinical and Diagnostic Research, v. 3, n. 3, p. 1537-1542, 2009.

PANAHI, Y. et al. Allopurinol mouth rinse for prophylaxis of fluorouracil‐induced mucositis. European Journal of Cancer Care, v. 19, n. 3, p. 308-312, 2010.

MEHDIPOUR, M. et al. A comparison between zinc sulfate and chlorhexidine gluconate mouthwashes in the prevention of chemotherapy-induced oral mucositis. Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences, v. 19, n. 1, p. 71, 2011.

CHOI, S.E.; KIM, H.S.. Sodium bicarbonate solution versus chlorhexidine mouthwash in oral care of acute leukemia patients undergoing induction chemotherapy: a randomized controlled trial. Asian Nursing Research, v. 6, n. 2, p. 60-66, 2012.

AHMED, K. M. The effect of olive leaf extract in decreasing the expression of two pro-inflammatory cytokines in patients receiving chemotherapy for cancer. A randomized clinical trial. The Saudi dental journal, v. 25, n. 4, p. 141-147, 2013.

AKHAVAN-KARBASSI, M. H. et al. Randomized doubleblind placebocontrolled trial of propolis for oral mucositis in patients receiving chemotherapy for head and neck cancer. Asian Pacific Journal of Cancer Prevention, v. 17, n. 7, p. 3611-3614, 2016.

GUPTA, Y. et al. Magic Mouth Wash V/s Benzydamine Mouth Wash in Prophylaxis and Treatment of Radiation Induced Oral Mucositis in Patients with Head and Neck Cancers: A Prospective Study. Indian Journal of Cancer Education and Research. v. 6, n. 1, 52-57, 2018.

CHITAPANARUX, Imjai et al. Randomized control trial of benzydamine HCl versus sodium bicarbonate for prophylaxis of concurrent chemoradiation-induced oral mucositis. Supportive Care in Cancer, v. 26, p. 879-886, 2018.

AFRASIABIFAR, A. et al. Grape vinegar and rose water solution versus chlorhexidine mouthwash for chemotherapy-induced oral mucositis: a randomized controlled trial. Complementary Therapies in Medicine, v. 50, p. 102–107, 2020.

SANTAELLA, N. G. et al. A comparative study on the perception and acceptance of polyhexanide and chlorhexidine mouthwashes in individuals at risk of developing oralmucositis induced by chemoradiotherapy. Brazilian Journal of Oral Sciences, v. 19, n. 8, e210062, 2020.

DALBETH, N.; MERRIMAN, T.R.; STAMP, L. K. Gout. Lancet, v. 388, p. 2039– 2052, 2016.

OSHIRO-SEMBOKUYA, M. et al. Evaluation of Disappearance Time and Palatability of Foams in the Oral Cavities of Healthy Volunteers, and Preparation of Drug-Containing Foam Formulations for Use in the Treatment of Oral Mucositis. Chemical and Pharmaceutical Bulletin, v. 69, n. 4, p. 400-406, 2021.

YENILMEZ, E.; ÖZTÜRK, A. A.; BAŞARAN, E. Preparation and in vitro, ex vivo evaluation of benzidamine hydrochloride loaded fast dissolving oral strip formulations: Treatment of oral mucositis due to side effects of chemotherapy and radiotherapy. Letters in Drug Design & Discovery, v. 20, n. 8, p. 1147-1157, 2023.

JONES, C. G. Chlorhexidine: is it still the gold standart? Periodontol, v. 15, p. 55-62. 1997.

MÜNSTEDT, Karsten; MÄNNLE, Heidrun. Using bee products for the prevention and treatment of oral mucositis induced by cancer treatment. Molecules, v. 24, n. 17, p. 3023, 2019.

Downloads

Publicado

2025-03-28

Como Citar

DELGADO COSTA, F. P.; DIAS, M. L. L. de S.; FERREIRA, P. H. G.; RODRIGUES, K. E. de S.; ABREU, L. G.; SILVA, T. A.; TRAVASSOS, D. V. Therapeutic alternatives with mouthwashes for management oral mucositis: an integrative review. Revista Unimontes Científica, [S. l.], v. 27, n. 1, 2025. DOI: 10.46551/ruc.v27n1a5. Disponível em: https://www.periodicos.unimontes.br/index.php/unicientifica/article/view/8505. Acesso em: 4 abr. 2025.

Edição

v. 27 n. 1 (2025)

Seção

Artigos de Revisão