RELAÇÃO DOS ELEMENTOS BIOQUÍMICOS E FARMACOLÓGICOS COM O DESENVOLVIMENTO DE COMPLICAÇÕES CARDÍACAS EM PORTADORES DE COVID-19: REVISÃO DE LITERATURA

Abstract

Justification and Objectives: The choice for this theme is important because it is a recently discovered disease that is generating a great impact worldwide, and is therefore of high scientific relevance. The objective was to describe the biochemical and pharmacological elements and their relationship with the development or worsening of cardiac changes in patients with COVID-19. Content: This is an integrative literature review with search for articles in three databases: Medical Literature Analysis and Retrieval System Online (MEDLINE), Latin American Literature in Health Sciences (LILACS) and SUS collections consulted through the Library Virtual Health (BVS Brasil), from June 1 to 18, 2020. 11 articles comprised this review. A flowchart was made showing the following topics: data collection; selection of records; analysis of the selection by title or abstract;
eligibility assessment; studies included for the construction of the synoptic framework. Conclusion: There is a relationship between COVID-19 and the development and / or worsening of cardiovascular changes, this relationship can be mediated by the action of the angiotensin-converting enzyme (ACE 2) and elevated levels of D-dimers. Patients with cardiovascular, hypertensive and diabetics have higher expression of ACE 2, which contributed to increase the chance of becoming infected by the virus. It was not possible to confirm whether antihypertensive drugs are related to the development of COVID-19.