Staphylococcus Aureus Co-infection as a Worsened Factor in Covid-19

Authors

DOI:

10.46551/ruc.v23n1a03

Keywords:

Coinfection. Staphylococcus aureus. COVID-19. Antibiotics.

Abstract

Objective: Investigate rates of occurrence of Staphylococcus aureus and SARS-CoV-2 coinfection and discuss the use of antimicrobials during this pandemic. Methods: This is an integrative literature review with the search for articles in the international medical database PubMed with the production of a flowchart that includes identification, selection, and inclusion of studies. Results: The publications found from the search in the PubMed database revealed that data on coinfection with S. aureus in COVID-19 patients are still scarce; however, they pay attention to a low coinfection rate. Although the statistical indexes are low, when there is this coinfection, it worsens COVID-19, increasing the lethality chance. Furthermore, suspected coinfections lead to antibiotics prescription, often empirical, which may favor the increase of resistant bacteria selection, the latter being a severe public health problem worldwide. Conclusion: In this sense, it is imperative to advise the antimicrobial's rational use, applying clinical-epidemiological guidelines, laboratory screening, and sensitivity testing to antimicrobials. These parameters ensure the correct treatment, control the selection of multiresistant strains, and assist patient safety. 

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Author Biographies

Luane Oliveira Araújo, Universidade de Brasília - UnB

Graduanda do curso de Farmácia pela Universidade de Brasília (UnB). Faculdade de Saúde, Universidade de Brasília, Campus Darcy Ribeiro, Asa Norte, Brasília-DF, 70910-900, Brasil. 

Paulo José Ferreira de Freitas, Universidade de Brasília - UnB

Graduando do curso de Farmácia pela Universidade de Brasília (UnB). Faculdade de Saúde, Universidade de Brasília, Campus Darcy Ribeiro, Asa Norte, Brasília-DF, 70910-900, Brasil. 

Joel Antônio Cordeiro de Abreu, Universidade de Brasília - UnB

Mestre em Ciências Genômicas e Biotecnologia e Graduando do curso de Farmácia pela Universidade de
Brasília (UnB). Faculdade de Saúde, Universidade de Brasília, Campus Darcy Ribeiro, Asa Norte, Brasília-DF, 70910-900, Brasil.

Natália Lopes de Freitas, Universidade de Brasília - UnB

Graduanda do curso de Farmácia pela Universidade de Brasília (UnB). Faculdade de Saúde, Universidade de Brasília, Campus Darcy Ribeiro, Asa Norte, Brasília-DF, 70910-900, Brasil. 

Fabiana Brandão, Universidade de Brasília - UnB

Pós-doutorado e Professora Adjunto do Departamento de Farmácia da. Universidade de Brasília (UnB).
Laboratório de Análises Clínicas, Departamento de Farmácia, Faculdade de Saúde, Universidade de Brasília, Campus Darcy Ribeiro, Asa Norte, Brasília-DF, 70910-900, Brasil. 

References

ZU, Z. Y. et al. Coronavirus Disease 2019 (COVID-19): A Perspective from China.

Radiology, Oak Brook, v. 296, n. 2, ago. 2020. Disponível em:

<http://pubs.rsna.org/doi/10.1148/radiol.2020200490>. Acesso em: 06 Abr. 2021.

TRINDADE, G. G. et al. COVID-19: therapeutic approaches description and

discussion. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 92, n. 2,

maio. 2020. Disponível

em:<http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-

&tlng=en>. Acesso em: 12 Maio 2021.

JIN, Y. et al. Virology, epidemiology, pathogenesis, and control of covid-19. Viruses,

Basel, v. 12, n. 4, p. 2–17, mar, 2020.

CHEN, G. et al. Clinical and immunological features of severe and moderate

coronavirus disease 2019. Journal of Clinical Investigation, New York, v. 130, n. 5,

p. 2620–2629, mar, 2020.

TAY M. Z. et al. The trinity of COVID-19: immunity, inflammation and intervention.

Nature Reviews Immunology, London, v. 20, n. 6, abr. 2020. Disponível

em:<http://dx.doi.org/10.1038/s41577-020-0311-8>. Acesso em: 06 Abr. 2021.

SHARIFIPOUR E. et al. Evaluation of bacterial co-infections of the respiratory tract in

COVID-19 patients admitted to ICU. BMC Infectious Diseases, London, v. 20, n. 1, p.

–7, set, 2020.

DANDAGI G. L. Nosocomial pneumonia in critically ill patients. Lung India, Mumbai,

v. 27, n. 3, p. 149–153, Jul-Set, 2010.

FATTORINI L. et al. Bacterial coinfections in COVID-19: an underestimated

adversary. Annali dell'Istituto superiore di sanita, Roma, v. 56, n. 3, jul. 2020.

Disponível em:<http://www.ncbi.nlm.nih.gov/pubmed/32959802>. Acesso em: 06

Abr. 2021.

VAN BELKUM A. et al. Reclassification of staphylococcus aureus nasal carriage

types. Journal of Infectious Diseases, Chicago, v. 199, n. 12, p. 1820-1826, maio,

WERTHEIM H. F. L. et al. The role of nasal carriage in Staphylococcus aureus

infections. Lancet Infectious Diseases, London, v. 5, n. 12, p. 751–762, dez, 2005.

MULCAHY M. E. et al. Staphylococcus aureus and influenza a virus: Partners in

coinfection. mBio, Washington, v. 7, n. 6, p. 4–7, dez, 2016.

OPATOWSKI L. et al. Influenza interaction with cocirculating pathogens and its

impact on surveillance, pathogenesis, and epidemic profile: A key role for

mathematical modelling. PLOS Pathogens, San Francisco, v. 14, n. 2, fev. 2018.

Disponível em:<https://dx.plos.org/10.1371/journal.ppat.1006770>. Acesso em: 08

Abr. 2021.

TASHER D. et al. Invasive bacterial infections in relation to influenza outbreaks,

-2010. Clinical Infectious Diseases, Chicago, v. 53, n. 12, p. 1199–1207, out,

WANG J. H. et al. Rhinovirus enhances various bacterial adhesions to nasal epithelial

cells simultaneously. Laryngoscope. Hoboken, v. 119, n. 7, p. 1406–1411, mar, 2009.

ALMAND E. A. et al. Virus-bacteria interactions: An emerging topic in human

infection. Viruses, Basel, v. 9, n. 3, p. 1–10, mar, 2017.

MIRZAEI R. et al. Bacterial co-infections with SARS-CoV-2. IUBMB Life, Oxford, v.

, n. 10, p. 2097–2111, jul, 2020.

CHERTOW D. S. et al. Bacterial coinfection in influenza: A grand rounds review.

JAMA - Journal of the American Medical Association, Chicago, v. 309, n. 3, p. 275–

, jan, 2013.

BENGOECHEA JA, Bamford CG. SARS-CoV-2, bacterial co-infections, and AMR:

the deadly trio in COVID-19?. EMBO Molecular Medicine, New Jersey, v. 12, n. 7, p.

–13, jun, 2020.

ZHOU F. et al. Clinical course and risk factors for mortality of adult inpatients with

COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet, London, v.

, n. 10229, mar. 2020. Disponível em:

<https://linkinghub.elsevier.com/retrieve/pii/S0140673620305663>. Acesso em: 08

Abr. 2021.

RAMADAN H. K-A. et al. Predictors of Severity and Co-Infection Resistance Profile

in COVID-19 Patients: First Report from Upper Egypt. Infection and drug resistance,

Auckland, v. 13, out. 2020. Disponível em:

<http://www.ncbi.nlm.nih.gov/pubmed/33116660>. Acesso em: 06 Abr. 2021.

RAWSON T. M. et al. Bacterial and Fungal Coinfection in Individuals With

Coronavirus: A Rapid Review To Support COVID-19 Antimicrobial Prescribing.

Antimicrobial Prescribing. Clinical infectious diseases: an official publication of the

Infectious Diseases Society of America, Chicago, v. 71, n. 9, out. 2020. Disponível

em:<https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa530/5828058>.

Acesso em: 06 Abr. 2021.

LANGFORD B. J. et al. Bacterial co-infection and secondary infection in patients

with COVID-19: a living rapid review and meta-analysis. Clinical Microbiology and

Infection, Oxford, v. 26, n. 12, dez. 2020. Disponível em:

<https://linkinghub.elsevier.com/retrieve/pii/S1198743X20304237>. Acesso em: 06

Abr. 2021.

LANSBURY L. et al. Co-infections in people with COVID-19 : a systematic review

and. Journal of Infection, London, v. 81, n. 2, maio 2020. Disponível em:

<https://doi.org/10.1016/j.jinf.2020.05.046>. Acesso em: 06 Abr. 2021.

CUSUMANO J. A. et al. Staphylococcus aureus Bacteremia in Patients Infected with

COVID-19: A Case Series. Open Forum Infectious Diseases, Cary, v. 7, n. 11, p. 5–

, 2020.

CROTTY M. P. et al. Investigation of subsequent and co-infections associated with

SARS-CoV-2 ( COVID-19 ) in hospitalized patients. medRxiv, v. 2, p. 1–19, jun.

ELABBADI A. et al. Bacterial coinfection in critically ill COVID-19 patients with

severe pneumonia. Infection, Munich, v. 49, n. 3, nov. 2020. Disponível em:

<https://doi.org/10.1007/s15010-020-01553-x>. Acesso em: 08 Abr. 2021.

CONTOU D. et al. Bacterial and viral co-infections in patients with severe SARSCoV-2 pneumonia admitted to a French ICU. Annals of Intensive Care, Paris, v. 10, n.

, set. 2020. Disponivel em:<https://doi.org/10.1186/s13613-020-00736-x>. Acesso

em: 08 Abr. 2021.

DUPLOYEZ C. et al. Panton-Valentine Leukocidin–Secreting Staphylococcus aureus

Pneumonia Complicating COVID-19. Emerging Infectious Diseases, Atlanta, v. 26, n.

, ago. 2020. Disponível em:<http://wwwnc.cdc.gov/eid/article/26/8/20-

_article.htm>. Acesso em: 06 Abr. 2021.

MAHMOUDI H. Bacterial co-infections and antibiotic resistance in patients with

COVID-19. GMS hygiene and infection control, Berlin, v. 15, dez. 2020. Disponível

em:<http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC7747008>.

Acesso em: 06 Abr. 2021.

GARCIA-VIDAL C. et al. Incidence of co-infections and superinfections in

hospitalized patients with COVID-19: a retrospective cohort study. Clinical

Microbiology and Infection, Oxford, v. 27, n. 1, Jul. 2020. Disponível

em:<https://linkinghub.elsevier.com/retrieve/pii/S1198743X2030450X>. Acesso em:

Abr. 2021.

ADEIZA S. S. et al. Random Effects Meta-Analysis of COVID-19/S. Aureus

Partnership in Co-Infection. SSRN Electronic Journal, New York, v. 15, p. 1–10, nov.

HUANG C. et al. Clinical features of patients infected with 2019 novel coronavirus in

Wuhan, China. The Lancet, London, v. 395, n. 10223, fev. 2020. Disponível

em:<https://linkinghub.elsevier.com/retrieve/pii/S0140673620301835>. Acesso em:

Abr. 2021.

LI J. et al. Etiology and antimicrobial resistance of secondary bacterial infections in

patients hospitalized with COVID-19 in Wuhan, China: a retrospective analysis.

Antimicrobial Resistance and Infection Control, London, v. 9, n. 1, p. 1–7, set. 2020.

YAP F. H. Y. et al. Increase in methicillin-resistant Staphylococcus aureus acquisition

rate and change in pathogen pattern associated with an outbreak of severe acute

respiratory syndrome. Clinical Infectious Diseases, Chicago, v. 39, n. 4, p. 511–516,

ago. 2004.

WHO. Global action plan on antimicrobial resistance [Internet]. World Health

Organization, editor. World Health Organization. World Health Organization; 2015. p.

–28. Disponível em:<https://www.who.int/publications/i/item/9789241509763>.

Acesso em: 10 Maio 2021.

DONÀ D. et al. Multi-drug-resistant infections in the COVID-19 era: a framework for

considering the potential impact. Journal of Hospital Infection, Burlington, v. 106, n.

, Maio 2020. Disponível

em:<https://linkinghub.elsevier.com/retrieve/pii/S0195670120302516>. Acesso em:

Abr. 2021.

HUGHES S. et al. Bacterial and fungal coinfection among hospitalized patients with

COVID-19: a retrospective cohort study in a UK secondary-care setting. Clinical

Microbiology and Infection, Oxford, v. 26, n. 10, out. 2020. Disponível em:

<https://linkinghub.elsevier.com/retrieve/pii/S1198743X20303694>. Acesso em: 08

Abr. 2021.

LAI C-C. et al. Co-infections among patients with COVID-19: The need for

combination therapy with non-anti-SARS-CoV-2 agents? Immunology and Infection, Hong Kong, v. 53, n. 4, ago. 2020. Disponível

em:<https://linkinghub.elsevier.com/retrieve/pii/S1684118220301274>. Acesso em:

Abr. 2021.

HUTTNER B. D. et al. COVID-19: don’t neglect antimicrobial stewardship

principles! Clinical Microbiology and Infection, Oxford, v. 26, n. 7, abr. 2020.

Disponível em:<https://doi.org/10.1016/j.cmi.2020.04.024>. Acesso em: 10 Maio

CLANCY C. J. et al. Bacterial Superinfections Among Persons With Coronavirus

Disease 2019: A Comprehensive Review of Data From Postmortem Studies. Open

Forum Infectious Diseases, Cary, v. 8, n. 3, fev. 2021.

RANDALL M. et al. Nosocomial methicillin-resistant Staphylococcus aureus

bacteremia in incarcerated patients with severe COVID-19 infection. American

Journal of Infection Control, Saint Louis, v. 48, n. 12, dez. 2020. Disponível

em:<https://doi.org/10.1016/j.ajic.2020.09.005>. Acesso em: 06 Abr. 2021.

PUNJABI C. et al. Prevalence of MRSA in Respiratory cultures and Diagnostic

Performance of the MRSA Nasal PCR in Patients hospitalized with COVID-19

Pneumonia. Infection Control and Hospital Epidemiology, Chicago, v. 2019, p. 1–2,

ago. 2020.

SPOTO S. et al. A staphylococcus aureus coinfection on a COVID-19 pneumonia in a

breast cancer patient. International Journal of General Medicine, Auckland, v. 13, p.

–733, set. 2020.

Published

2021-06-18

How to Cite

ARAÚJO, Luane Oliveira; FREITAS, Paulo José Ferreira de; ABREU, Joel Antônio Cordeiro de; FREITAS, Natália Lopes de; BRANDÃO, Fabiana. Staphylococcus Aureus Co-infection as a Worsened Factor in Covid-19 . Revista Unimontes Científica, [s. l.], vol. 23, no. 1, p. 1–20, 2021. DOI: 10.46551/ruc.v23n1a03. Disponível em: https://www.periodicos.unimontes.br/index.php/unicientifica/article/view/4310. Acesso em: 3 jul. 2024.

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