Biomarkers in Chagas cardiomyopathy as diagnostic, risk and prognostic predictors

updates and associations

Authors

DOI:

10.46551/ruc.v25n1a1

Keywords:

chagasic cardiomyopathy, Risc, Biomarkers

Abstract

Objective: to report the various biomarkers described for Chagas cardiomyopathy, describing the clinical and pathophysiological significance in different contexts, isolated or combined, diagnosis, prognosis, risk and outcome. Method: This is an integrative literature review with a search for articles in the Medical Literature Analysis and Retrieval System Online (MEDLINE) database, consulted through the Virtual Health Library (BVS) and PubMed databases, using the Health Sciences Descriptors (DeCS) and Medical Subject Headings (MeSH), Chagas cardiomyopathy, Biomarkers, Risk, with a time frame from January 2012 to December 2021. A flowchart was prepared with the stages of identification, selection and inclusion of studies, and two tables were constructed to allow visualization of the structure and organization of the content. Results: 46 studies located in the MEDLINE database, observing the criteria of the PRISMA method, resulted in 11 articles included in the review, mostly cohort studies. Final considerations: The biomarkers BNP, NT-proBNP, Troponin, CKMB, with evidence related to severity and risk in Chagas cardiomyopathy, already known, showed consistent associations. MMP-2, MMP-9, TIMP-1 and TIMP-2, TNF-α, IL-6, IL-8, IL-10, showed significant associations. Galectin-3, vimentin, 8-OHdG, copeptin, endostatin, hnRNPA1, DHEA-S, cystatin C, also with significant associations and with prospects for further studies.

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Author Biographies

Guilherme Moreira Pimenta, Universidade Estadual de Montes Claros

Mestre em Biotecnologia. Universidade Estadual de Montes Claros (UNIMONTES). Doutorando em Ciências da Saúde. Universidade Estadual de Montes Claros (UNIMONTES). Montes Claros - MG - Brasil.

Ludmilla Louise Cerqueira Maia Prates, Universidade Estadual de Montes Claros

Mestre em Ciências da Saúde. Universidade Estadual de Montes Claros (UNIMONTES). Doutoranda em Ciências da Saúde. Universidade Estadual de Montes Claros (UNIMONTES). Montes Claros - MG - Brasil.

Diego Patrick Soares Lopes, Universidade Estadual de Montes Claros

 Mestre em Fisiologia Humana. Universidade Federal da Bahia (UFBA). Doutorando em Ciências da Saúde. Universidade Estadual de Montes Claros (UNIMONTES). Montes Claros - MG - Brasil.

Hector Gustavo  Arango, Professor da Faculdade de Ciências Sociais Aplicadas do Sul de Minas (FACESM)

Doutor em Ciências da Engenharia. Universidade Federal de Itajubá (UNIFEI). Itajubá – MG – Brasil. Professor da Faculdade de Ciências Sociais Aplicadas do Sul de Minas (FACESM). Itajubá – MG – Brasil.

 

 

Sergio Avelino Mota Nobre, Universidade Estadual de Montes Claros

Doutor em Ciências pela Universidade Federal de Viçosa (UFV). Viçosa – MG, Brasil – Professor da Universidade Estadual de Montes Claros (UNIMONTES). Montes Claros – MG, Brasil.

Mariléia Chaves Andrade, Universidade Estadual de Montes Claros

Doutora em Imunologia pela Universidade Federal de Minas Gerais (UFMG). Belo Horizonte – MG – Brasil. Professora da Universidade Estadual de Montes Claros (UNIMONTES). Montes Claros - MG - Brasil. Professora da Faculdade de Medicina de Itajubá (FMIT- Afya Group.). Itajubá – MG – Brasil.

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Published

2023-01-31

How to Cite

MOREIRA PIMENTA, G.; CERQUEIRA MAIA PRATES, L. L.; SOARES LOPES, D. P.;  ARANGO, H. G.; MOTA NOBRE, S. A.; CHAVES ANDRADE, M. Biomarkers in Chagas cardiomyopathy as diagnostic, risk and prognostic predictors: updates and associations. Revista Unimontes Científica, [S. l.], v. 25, n. 1, p. 1–27, 2023. DOI: 10.46551/ruc.v25n1a1. Disponível em: https://www.periodicos.unimontes.br/index.php/unicientifica/article/view/5472. Acesso em: 24 nov. 2024.

Issue

Vol. 25 No. 1 (2023): REVISTA UNIMONTES CIENTÍFICA

Section

Artigos de Revisão

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