Phytochemical Characterization of Aqueous Leaf Extracts from Cerrado Plant Species and Pharmacological Implications

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DOI:

10.46551/ruc.v26n2a7

Abstract

Objective: To perform the phytochemical characterization of leaf extracts from five plant species of the Cerrado biome (Casearia sylvestris, Schinopsis brasiliensis, Serjania lethalis, Piptadenia viridiflora, and Ximenia americana) and discuss their pharmacological implications. Methods: The study was conducted using high-performance liquid chromatography (HPLC). Aqueous extracts of the leaves were analyzed to identify the classes of bioactive compounds present. The samples were prepared by infusion with distilled water, followed by separation and analysis using HPLC. Results: The results revealed flavonoids as the main class of plant compounds present in the studied species, Casearia sylvestris, Schinopsis brasiliensis, Serjania lethalis, Piptadenia viridiflora, and Ximenia americana. However, other classes such as alkaloids, tannins, saponins, and triterpenes/steroids were also highlighted in the study. The presence of these compounds in the studied species suggests a broad spectrum of biological activities and potential therapeutic applications, such as antioxidant, anti-inflammatory, antimicrobial, immunomodulatory, and antitumor properties.Conclusion: The presence of metabolites such as flavonoids, alkaloids, tannins, saponins, and triterpenes/steroids demonstrates the phytochemical diversity of Cerrado species, highlighting the potential of this biome for the development of new drugs based on natural compounds. This underscores the importance of conservation and ongoing scientific exploration of this ecosystem.

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Author Biographies

Otávio Cardoso Filho, Universidade Estadual de Montes Claros

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Franciellen Morais Costa, Universidade Estadual de Montes Claros

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Mylena Oliveira Andrade, Universidade Estadual de Montes Claros

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Eduardo Robson Duarte, Universidade Estadual de Montes Claros

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Viviane de Oliveira Vasconcelos, Universidade Estadual de Montes Claros

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References

BARBOSA, Antônio. Área do Cerrado. Estudos sobre a geografia e ecossistemas do Cerrado. 2017.

SANO, Shuichi M., Almeida, Spenser P., & Ribeiro, José F.Cerrado: ecologia e flora. Embrapa Informação Tecnológica. 2010.

CASTRO, Antonia et al. How rich is the flora of the Cerrado and how many of its species are we losing? Annals of the Missouri Botanical Garden, v. 93, n. 2, p. 194-220, 2016.

CARMIGNOTTO, Ana P., & Aires, Caroline C. Mammals of the Cerrado and their conservation. In: Oliveira, Paulo S., Marquis, Robert J. (Eds.), The Cerrados of Brazil: Ecology and Natural History of a Neotropical Savanna. Columbia University Press. 2012.

GODINHO, Letícia B., Costa, Gabriel M., & Borges, Mariana E. P. Phytochemical study of medicinal plants from the Cerrado. Revista Brasileira de Plantas Medicinais, v.17, n. 2, p. 226-234, 2015.

CASTRO, Maria V., Eberlin, Marcos N., & Costa, Jorge L. Identification of chemical constituents of medicinal plants from Brazilian Cerrado by electrospray ionization mass spectrometry. Journal of Mass Spectrometry, v. 39, n. 8, p. 998-1003, 2014.

DELBONE, Cristina A. C., & Lando, Marcos. The defensive role of secondary metabolites in plants: a review of scientific literature. Journal of Plant Biology, v. 54, n. 3, p. 214-222, 2010.

SILVA, Fernanda C., Almeida, Victor P., & Barbosa, Luís C. A. Secondary metabolites: definition, function, and biosynthesis. Natural Products Chemistry & Research, v. 6, n. 2, p. 1-8, 2018.

BRAIBANTE, Maria E. F., Lima, Lucas P., & Ferreira, Ana G. Utilização de plantas medicinais no Cerrado brasileiro: uma abordagem etnobotânica. Revista Brasileira de Plantas Medicinais, v. 16, n. 2, p. 411-419, 2014.

DUARTE, Ana L. Phytochemistry and therapeutic applications of bioactive compounds from Cerrado plants. Revista Brasileira de Farmacognosia, v. 16, n. 2, p, 188-195, 2006.

LIMA, Vera L. A. G., Melo, Edna A., & Maciel, Mônica I. S. Antioxidant activity of bioactive compounds from Cerrado plants. Brazilian Journal of Pharmacognosy, v. 21, n. 2, p. 260-267, 2011.

MORAIS-COSTA, Fernanda, Oliveira, Daniel S., & Pimenta, Luís P. S. Preparation of aqueous extracts from Cerrado plants for phytochemical analysis. Journal of Applied Sciences, v. 10, n. 4, p. 315-321, 2015.

VALADARES, Maria C., Sousa, Cláudia M. M., & Costa, Jorge M. Chromatographic separation and analysis of bioactive compounds from medicinal plants. Brazilian Journal of Analytical Chemistry, v. 30, n. 1, p. 42-48, 2003.

KUMAR, Sanjay, & Pandey, Avinash K. Chemistry and biological activities of flavonoids: an overview. The Scientific World Journal, 2013.

PANCHE, Anil N., Diwan, Anil D., & Chandra, Sanjay R. Flavonoids: an overview. Journal of Nutritional Science, 5, e47. 2016.

BUZZINI, Pietro, Arapitsas, Panagiotis, Goretti, Michele, Branda, Elisa, Turchetti, Benedetta, Pinelli, Paola, ... & Romani, Annalisa. (2008). Antimicrobial and antiviral activity of hydrolysable tannins. Mini Reviews in Medicinal Chemistry, v. 8, n. 12, p. 1179-1187, 2008.

SCALBERT, André. Antimicrobial properties of tannins. Phytochemistry, v. 30, n. 12, p. 3875-3883, 2018.

MAN, Shijun et al. Chemical study and medical application of saponins as anti-cancer agents. Fitoterapia, v. 81, n. 7, p. 703-714, 2010.

MILGATE, James, & Roberts, David C. K. The nutritional and biological significance of saponins. Nutrition Research, v. 15, n. 8, p. 1223-1249, 1995.

FACCHINI, Peter . Alkaloid biosynthesis in plants: biochemistry, cell biology, molecular regulation, and metabolic engineering applications. Annual Review of Plant Biology, v. 52, n. 1, p. 29-66, 2001.

MAHATO, Satyajit B., & Sen, Saikat. Advances in triterpenoid research, 1990-1994. Phytochemistry, v. 44, n. 7, p. 1185-1236, 1997.

OSTLUND, Richard E. Jr. Phytosterols and cholesterol metabolism. Current Opinion in Lipidology, v. 13, n. 1, p. 41-48, 2002.

Published

2024-09-24

How to Cite

FILHO, O. C.; COSTA, F. M.; ANDRADE, M. O.; PIMENTA CRUZ, J.; DUARTE, E. R.; VASCONCELOS, V. de O. Phytochemical Characterization of Aqueous Leaf Extracts from Cerrado Plant Species and Pharmacological Implications. Revista Unimontes Científica, [S. l.], v. 26, n. 2, 2024. DOI: 10.46551/ruc.v26n2a7. Disponível em: https://www.periodicos.unimontes.br/index.php/unicientifica/article/view/7838. Acesso em: 21 nov. 2024.

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